Description
Mary & May Spicule Retinol PDRN Cream 15g is a concentrated Korean nighttime treatment developed to improve the appearance of rough texture, enlarged-looking pores, fine lines and reduced firmness. Its fragrance-free formula combines marine-derived micro-spicules with nano-liposome retinol, CICA PDRN and moisture-barrier-supporting ingredients.
The formula contains 2,000 ppm natural marine-derived micro-spicules, listed as Hydrolyzed Sponge in the ingredient list. Mary & May describes the spicules as approximately 80–300 micrometres in size. According to the brand, one 15g tube contains approximately 180,000–200,000 microscopic spicules.
These micro-spicules create temporary physical stimulation at the skin’s surface. A mild prickling or tingling sensation may be noticeable during application and when the treated area is touched. This sensation should be distinguished from persistent burning, swelling or severe redness.
The formula also contains 1,000 ppm nano-liposome retinol. Encapsulation is designed to improve the stability and delivery of retinol while supporting a more controlled application experience. Retinol helps accelerate the appearance of surface renewal and supports smoother texture, refined-looking pores, improved firmness and reduced visibility of fine lines.
CICA PDRN complements the active formula with soothing and recovery-focused cosmetic care. Sodium DNA is included in the ingredient list and supports the product’s PDRN positioning. Claims should remain focused on healthier and recovered-looking skin rather than medical regeneration.
Panthenol is included at 2%. Also known as provitamin B5, panthenol helps replenish moisture, support the skin’s natural barrier and reduce the uncomfortable feeling associated with dryness. Its soothing hydration is especially relevant in a formula containing both retinol and micro-spicules.
Ceramide NP and cholesterol provide lipid-based barrier support. These ingredients help maintain the skin’s protective moisture barrier and complement the formula’s active texture-care ingredients.
Sodium Hyaluronate and polyglutamic acid help attract and retain moisture at the skin’s surface. They support a softer, smoother and more supple appearance while helping reduce the feeling of tightness.
Allantoin provides additional soothing and skin-conditioning benefits. Shea butter, macadamia seed oil and Caprylic/Capric Triglyceride complement the formula with nourishing emollient care.
Niacinamide supports brighter, more even-looking skin while complementing visible pore and sebum care. Adenosine contributes to the formula’s fine-line and elasticity-focused positioning.
Tocopherol, sunflower seed oil, beta-carotene and hydrogenated lecithin support formula stability, conditioning and antioxidant care. These ingredients complement the retinol system and help maintain a comfortable cream texture.
Mary & May states that the product has completed a skin irritation test. The brand also references testing associated with the appearance of pore depth, pore area, pore density, eye wrinkles, smile lines, skin texture and firmness. Individual results can differ according to skin condition, frequency, tolerance and sunscreen use.
The cream is intended primarily for evening use. Beginners should apply it once weekly at first and increase frequency gradually. It should not initially be layered with exfoliating acids, physical scrubs, strong vitamin C treatments, benzoyl peroxide or additional retinoids.
Because the formula contains retinol, consistent daytime sunscreen is essential. People who are pregnant, planning pregnancy or breastfeeding should obtain guidance from a qualified healthcare professional before using a retinoid product.
This Spicule Retinol PDRN Cream is most suitable for experienced skincare users concerned with rough texture, visible pores, fine lines and reduced firmness. People with highly reactive, actively inflamed or damaged skin should avoid applying it until the skin has recovered.
Key Ingredients & Benefits
🪸 2,000 ppm Marine Micro-Spicules – Support targeted texture and visible pore care
🌙 1,000 ppm Nano-Liposome Retinol – Supports renewal and fine-line care
🧬 CICA PDRN – Complements soothing and recovered-looking skin care
💧 2% Panthenol – Supports hydration, comfort and the moisture barrier
🧱 Ceramide NP & Cholesterol – Provide lipid-based barrier support
💦 Sodium Hyaluronate – Helps maintain surface hydration and suppleness
🌿 Allantoin – Supports a calmer and more comfortable skin feel
✨ Niacinamide – Supports brighter, more even-looking skin
🌙 Adenosine – Complements elasticity and wrinkle-care benefits
🚫 Fragrance-Free – Contains no added artificial fragrance





Reviews
There are no reviews yet.